C-Type Lectin Domain Family 4 Member L (CD209) Antibody
英文名字
C-Type Lectin Domain Family 4 Member L (CD209) Antibody
供应商
Abbexa
产品货号
abx034379
产品报价
¥询价/80ul ¥询价/400ul
产品说明书
购买方式
银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868。
产品新闻
背景资料
CD209 encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution.
应用类型
WB
免疫原
C-Type Lectin Domain Family 4 Member L (CD209)
来源宿主
兔
反应性
人
保存建议
建议收到该C-Type Lectin Domain Family 4 Member L (CD209) Antibody产品后,储存温度为-20°C。避免重复冻融